Objective To investigate the relationship of vascular endothelial growth factor c(VEGF-C) and induced nitride ox- ide synthesizase(iNOS) expression in lymph node micrometastasis of oral squamous cell carcinoma.Methods Samples were ob- tained from 47 cases of oral squamous cell carcinoma and 15 caseswith normal oral mucosa, VEGF-C and iNOSmRNA expression were detected by RT-PCR method. Lymph node micrometastasis of 10 normal lymph nodes and 355 lymph nodes from 47 cases of oral squamous cell carcinoma was detected with immunohistochemical reaction in cytokeratin antibody.Results The percentages in tumorswith higher expressionwere 57·4% forVEGF-C, 68·1% for iNOS(P