Objective To explore the feasibility of bovine pericardium used as a material for guiding bone regeneration. Methods 1 cm x 1 cm x 0.5 cm defects were created on both buccal sides of the mandibles of II dogs. One side was covered with Gl- utaraldehyde (GA) cross-linking bovine pericardium; no membrane covered side was used as control. The animals were sacrificed in 2 weeks, 4 weeks, 8 weeks and 16 weeks after operation to observe the repair of the bone defects. Results 0Wounds healed well in 10 dogs. Meanwhile, wounds in dogs of 16 weeks group healed badly and severe inflammatory response was found in bovine pericardium treated area.②The pericardium can be maintained in vivo for 16 weeks without absorption, there were only mild infammatory cells invading.③ The bone defects covered with bovine pericardium repaired better than control groups significantly. Conclusion (I)GA bovine pericardium have the effect on guiding bone regeneration in the repair of dog experimental bone defects and it is possible that the bovine pericardium will be used as a new kind of GBR material;②GA bovine pericardium has good biocompatibility.
