Objective To investigate the clinical multimanifestation, diagnosis and treatment of non-Hodgkin's lymphoma in oral, maxillofacial and cervical regions. Methods 58 cases of non-Hodgkin's lymphoma in oral, maxillofacial and cervical re- gions were retrospected in this study. Results The manifestatiomof 58 cases was complicated. Non-Hodgkin's lymphoma treat- merit was synthetical therapy or chemical therapy. Conclusion Nat-Hodgkin s lymphoma in oral, maxillofacial and cervical re- gions had multi-manifestation and higher malignant, The final diagnosis relied on pathological examination. Both of sythetical ther- apy and chemical therapy were effective to non-Hodgkin's lymphoma in oral, maxillofacial and cervical regions.