Objective To discuss the function ofMMP-9,MMP-2 in the remodeling bone tissue around implant during unload- ed period.Methods At the anterior of the maxilla and mandibular of the Beagle dog, implants were placed at different periods, so the implant specimens of different periods were obtained after dogs were killed. The implant specimens were removed, fixed in 4% prarformaldehyde for 24 hours at 4℃, decalcifiedwith 10% EDTA at pH7.2, embedded in paraffinwax and sectioned. The observation of the expression changes of theMMP-2, MMP-9 in the milien bone tissue of the implant at different periodswere taken by immunohistochemical staining.Results Matrix metalloprotainase (MMP-9) was mostly expressed at the peripheral cytoplasmic of osteoclast, macrophage, lining cell and fibroblast. MMP-2 was mostly expressed at the peripheral cytoplasmic of osteoblast, fi- broblast, some osteoclast also expressed this enzyme.Conclusion MMP-2 and MMP-9 have an important function at the injured bone absorption, healing and bone remodeling after dental implant placement.
