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论文摘要

口底鳞状细胞癌形态计量学研究的临床意义

Clinic Significance of Morphometric Study on Squamous Cell Carcinoma of Floor of Mouth

作者:赵洪伟1,李龙江1,谢文扬2

Author:ZHAOHong-wei1, LILong- jiang1,XIE Wen-yang2

收稿日期:2004-06-25          年卷(期)页码:2004,22(03):220-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:口底鳞状细胞癌,形态计量,图像分析,

Key words:squamous cell carcinoma of floor of mouth,morphometry,image analysis,

基金项目:

中文摘要

目的 探讨细胞形状因子(FC)和平均光密度参数在口底鳞癌诊断中的意义。方法 28例口底鳞癌石蜡标本切片免疫组化(SABC)染色,应用图像分析仪测定原发灶和颈淋巴结细胞胞核形状因子(FC)和平均光密度参数。结果 经CK10和CK14单克隆抗体标记后,淋巴结有无转移或病理分级不同患者的原发灶细胞胞核中FC和平均光密度参数有显著性差异(P0·05);颈淋巴结中转移阳性和阴性间的FC和平均光密度有显著性差异(P

英文摘要

Objective The purpose of this study was to investigate the role of cell morphometric factor (FC) and the average density of light in squamous cell carcinomas at the floor of mouth by immunohistochemical method (SABC).Methods The slices made from the paraffin specimens of 28 patients with squamous cell carcinomas at the floor of mouthwere stained by the immuno- histochemical technique withmonoclonal antibody CK10and CK14.In these stained slices the FC parameters and the average density of light were measured by using an image analysis system.Results In primitive tumors, the FC parameters and the average den- sity of light were significantly different between positive and negative lymph nodes metastasis or between different pathological grades(P0.05). The difference of FC expressed in positive and negative lymph nodesmetastasiswere significant(P

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