Objective The purpose of this article was to observe the effect of Vitapex Paste in apexification.Methods 64 younger permament teeth with underdeveloped apex and necrotic pulpwere randomly selected. After root canalswere prepared and sterilized, Vitapex paste was used in the apexification. All the teeth were observed for three years.Results 24 teeth(37.5%) were successful, 37 teeth (57.81%) were progressive, 3 teeth (4.69%) were failed. Altogether 61 teethwere effective, the ef- fective rate was 95.31%.Conclusion Vitapes paste was effective for the younger permanent teeth in the apexification.