Objective The purpose of this study was to evaluate the advantages and disadvantages of vascularized free pero- neal flap as a newmethod for reconstruction of oral and maxillofacial defects.Methods Twenty-one cases received reconstruction of oral and maxillofacial defectswith free vascularized peroneal flaps in our hospitalwere studied retrospectively. All of the relevant data of operation, such as the cause of the defect, design of the flaps, the recipient vessels of the recipient and the complications were investigated.Results Twenty cases survived, the average size of the vascularized free peroneal flapwas 8·5 cm×5·25 cm. Conclusion It is safe and reliable to use free peroneal flap to reconstruct the oral maxillofacial defects.