聚D,L乳酸螺钉复合骨形成蛋白行骨折内固定的实验研究
The Experimental Study of PDLLA/rhBMP-2 Compound Screws for Internal Fixation of Mandibular Fracture
作者：罗恩,周立伟,魏世成,郑谦,宁秋
Author：LUO En,ZHOULiwei,WEIShicheng,et al
收稿日期：2003-12-25 年卷（期）页码：2003,21(06):422-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：聚D,L乳酸,重组人骨形成蛋白-2,骨折内固定,骨诱导,
Key words：poly D,L-lactic acid,recombination human bone morphogenetic proteins-2,internal fixation of fracture,bone induction,
基金项目：本课题为四川省科技厅重点资助项目(2001年)
中文摘要
目的 观察聚D,L乳酸螺钉复合骨形成蛋白(rhBMP-2)植入骨组织后对钉道骨缺损及周围骨折愈合的作用。方法 采用自身对照研究,将聚D,L乳酸与rhBMP-2复合后附着于聚D,L乳酸螺钉凹槽内,植入固定4 只犬的下颌颏部骨折,并与聚D,L乳酸螺钉对照。术后4、8、12、16周取标本行X线和组织学观察。结果 实验侧复合螺钉钉道骨缺损及周围骨折处的成骨程度明显比对照侧强;骨折断端固定愈合良好。结论 聚D,L乳酸复合 rhBMP-2螺钉对钉道骨缺损及周围骨折愈合具有明显促进作用,对骨折愈合能起到良好的固定作用。
英文摘要
Objective To study the effect of poly D,L-lactic acid (PDLLA) screws with PDLLA-rhBMP compound on bone regeneration in the screwholes and fracture ends of dogmandibles.Methods Aself-control studywas carried out in 4 dogs. PDLLA/rhBMP-2 compound screws were implanted to fix the mental fractures and PDLLA screws were used as control. The sam- ples from mandibleswere collected at 4, 8, 12, 16 weeks after implantation and observed by radiography and histology.Results All dogs showed a greater degree of bone regeneration around PDLLA/rhBMP-2 screws than PDLLA ones and all fractures were fixed and healed well.Conclusion The PDLLA-rhBMP screwhas a better effect of inducing osteogenesis than PDLLAscrew, and is able to exert a good fixation to fracture.
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