特异性抗变形链球菌鸡蛋黄抗体IgY对定菌鼠龋齿发生的影响
The Study on Specific Anti_Streptococcus mutansIgY Against Dental Caries in Rats
作者：樊明文,江千舟,边专,李宇红,刘宁慧
Author：FANMingwen*,JIANGQianzhou,BIANZhuan,et al.
收稿日期：2003-10-25 年卷（期）页码：2003,21(05):339-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：龋病,定菌鼠,变形链球菌,
Key words：caries,gnotobiotic rats,streptococcus mutans,
基金项目：本课题为湖北省科委科技攻关项目(编号982 P 1602)
中文摘要
目的 研究特异性抗变IgY形链球菌鸡蛋黄抗体对定菌鼠龋齿发生、发展的影响。方法 将35只 Wistar大鼠随机分为5组,接种耐链霉素的S.mutansMT 8148,并给予致龋饲料,使用特异性抗变链的鸡蛋黄抗体 IgY通过不同方式对实验动物进行被动免疫。实验结束后,根据Keyes评分方法作龋齿计分,并采用t检验进行统计分析。结果 在食物中添加特异性IgY冻干粉或经口腔喷雾IgY漱口水均能显著降低大鼠牙釉质及牙本质外层龋齿计分。给予含特异性抗体的鸡蛋黄饮食能减低龋齿的发生,但与对照组比较无显著性差异。结论 特异性抗变链的鸡蛋黄抗体IgY能减少定菌鼠龋齿的发生,减缓龋齿的发展。
英文摘要
Objective To investigate the effect of specific anti_streptococcus mutansIgY againststreptococcus mutanson dental caries development in rats.Methods 35 wistar rats were divided into 5 groups: group A received IgY gargle; group B received IgY lyophilized powder; group C received sterilized water as control; group D and E received egg yolk food with orwith- out specific IgY individually. Theywere all fed with caries_inducing diet 2000#. The number of caries scoreswas counted by the procedure of Keyes′.Results There was a significant lower mean of caries scores in groups treated with IgY lyophilized powder and gargle. Bytreatingwith egg_yolk food contained specific IgY, the mean of caries scores decreased comparingwith notreatment group.Conclusion Local passive immunization with specific anti_streptococcus mutans IgY may be an effective way to prevent the development of dental caries.
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