Objective:The aim of this study was to evaluate the effects of different free flap transfers for head and neck reconstruction in a new microsurgery unit. Methods: 150 consecutive free flap transfers performed in 144 patients from May 1999 to October 2000 were reviewed. Data concerning the operation included date of surgery, defect description and site, stage and histology of tumor, flap type, recipient vessel and type of anastomosis used and complications. Results: The free radial forearm flaps were the commonest flaps used, and followed by free fibula flaps, rectus abdominis flaps, scapular flaps, illiac crest flaps, and latissimus dorsi flaps. The success rate of all flaps was 98% . The overall complication rate was 34% . The vessel thrombosis rate was 6% , and the flap salvage rate was 66.7% . Conclusion: Free tissue transfer in head and neck region is safe and reliable and, is superior to the conventional pedicled flap technique.