Objective To compare the effects of dexmedetomidine and midazolam with fentanyl with anticipated difficult intubation during awake blind nasal intubation on respiration and hemodynamics of patients.Methods Forty patients(ASA class Ⅰ toⅡ) undergoing selective oral and maxillofacial surgeries with anticipated difficult intubation were enrolled in the study. The patients were randomly assigned into two equal groups. Experimental group received dexmedetomidine, control group received midazolam and fentanyl. The Ramsay sedation scores, mean artery pressure(MAP), heart rate(HR), respiratory rate(RR) and blood oxygen saturation of pulse(SpO2) were recorded at baseline(T1), beginning to intubate(T2), 10 min after beginning to intubate(T3), 20 min after beginning to intubate(T4), and after intubation(T5). The operative time for intubation, intubation times, success rate of intubation, the anesthetic effects and complications were recorded.Results The success rate in the experimental group was significantly higher than that in the control group(P0.05). The Ramsay sedation scores in the control group were lower than those in the experimental group(PConclusion Appropriate application of dexmede-tomidine can be safer and more effective than midazolam with fentanyl for awake blind intubation.
