人体真菌组与疾病
Human mycobiome and diseases
作者：沈鑫,姚羽菲,李继遥,李燕
Author：Xin Shen,Yufei Yao,Jiyao Li,Yan Li
收稿日期：2018-12-21 年卷（期）页码：2019,37(3):314-314-319
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：真菌组,疾病,细菌组,相互作用,宿主免疫反应,
Key words：mycobiome,diseases,bacteriome,interaction,hostimmune response,
基金项目：国家自然科学基金面上项目(81771085);四川省卫生和计划生育委员会重点项目(16ZD021)
中文摘要
真菌组在人体微生物组中所占比例不到1%,但真菌群落在人体健康与疾病状态中扮演着关键角色。近年来随着高通量测序技术的广泛应用,人体不同部位如口腔、肺部、消化道、阴道以及皮肤真菌组的结构和组成被解析,其在人体健康和疾病中的重要地位也被挖掘。同时,人体真菌组对细菌组的组成也有影响,是维持微生物组结构和代谢功能稳定的关键物种;真菌组对宿主的免疫应答作用也对某些疾病的发生发展有显著影响。本文综述了人体不同部位健康与疾病状态下真菌组组成情况以及真菌组与细菌组、宿主免疫的相互作用。
英文摘要
The proportion of mycobiome is less than 1% of human microbiome. However, fungal community plays a key role in human health and diseases. With high-throughput sequencing applications, the structure and composition of mycobiome in the mouth, lung, gut, vagina, and skin have been analyzed, and the role of microbiome in diseases has been investigated. Mycobiome also influences the composition of bacteriome and includes key species that maintain the structure and function of microbial communities. Fungi also influence host immune responses. In this review, we summarized the mycobiome composition at various sites and different diseases and the interactions between fungi-bacteria and fungi-host.
上一条：成釉细胞和成牙本质细胞的极性及其相关调控分子
【关闭】
