环状RNA与口腔鳞状细胞癌研究进展
Research progress on circular RNA in oral squamous cell carcinoma
作者：雷可昕, 白贺天, 杨淞月, 李敬, 陈谦明
Author：Lei Kexin, Bai Hetian, Yang Songyue, Li Jing, Chen Qianming
收稿日期：2018-10-18 年卷（期）页码：2020,38(4):425-425-430
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：环状RNA,成环机制,生物学功能,口腔鳞状细胞癌,生物标记物,
Key words：circular RNA,biogenesis of circRNA,biology function,oral squamous cell carcinoma,biomarker,
基金项目：国家自然科学基金(81872211);国家自然科学基金(81672675);国家自然科学基金(81621062);高等学校学科创新引智计划(B14038);中国科协青年人才托举工程(2017QNRC001);四川大学大学生创新实验项目(20171083)
中文摘要
环状RNA（circRNA）是一种在真核生物中广泛存在的闭合环状非编码RNA,其生成机制、生物学功能的研究进展显示环状RNA可能在包括肿瘤、神经系统疾病、心血管疾病的发生发展过程中扮演重要角色,具有作为疾病标志物的潜能。口腔鳞状细胞癌（OSCC）是口腔外科最常见的恶性肿瘤之一,具有难治疗、易转移、预后差等的特点,由于其发生机制尚不明确,从基因层面阻断OSCC尚不能实现。而环状RNA在OSCC领域的研究进展将为OSCC的生物治疗带来新的思路。本文归纳综述了环状RNA的成环机制、生物学功能及在肿瘤尤其是OSCC发展中的研究进展。
英文摘要
Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.
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