Diseases of oral mucosa are characterized by complex etiology, diverse and confused clinical manifestations, as well as lack of special therapeutic drugs and methods. So it has always been a non-evasive teaching conundrum. This paper explored a multiple three-dimensional interactive teaching mode, a combination of problem-based learning（PBL）, case-based learning（CBL）, multimedia, internet and evidence-based medicine. It is hoped that its application in the teaching of the diseases of oral mucosa will arouse the students’learning interest, broaden their professional perspective, cultivate their self-learning ability to find, ask, analyze and solve problems, and strengthen their clinical practice capacity.
