Objective To study the short-term effects of nociceptive trigeminal inhibitory tension suppression system(NTI-tss) and occlusal stabilization splint(OS) on sleep bruxism patients. Methods Ten patients received the two splint treatments in a randomized cross-over fashion:An NTI-tss and an OS for a 1-week period, respectively. Record the bruxism episodes per hour, micro-arousals per hour of the patients before wearing the splints(baseline), the first night and 1 week after wearing the splints with polysomnography. Statistical analysis was performed with SAS 9.1 by means of mixed effect model analysis. Results There were no differences among the micro-arousal index of the baseline, the first night and 1 week later with both types of the splints(P>0.05). The NTI-tss was associated with a significant reduction in bruxism index compared with baseline. The bruxism index of baseline, the first night and 1 week later were 7.50±1.11, 3.45±1.22, and 3.51±1.03 per hour(the first night vs baseline, t=26.52, Pthe treatment of sleep bruxism.