Objective To measure the magnitude of galvanic currents produced by different occluding metallic contact. Methods The circuits of instantly different metallic contact were simulated in artificial saliva, and electrical potential of every couple and 15 currents of instant contact were then measured. After 8 hours′ soaking, 15 currents were obtained in addition. Results Galvanic currents variation produced by intermittently metallic contact was ruleless. During early soaking, gold/titanium, gold/high zinc-containing amalgam and low/high zinc-containing amalgam exhibited much higher current, and there was significant difference on currents between titanium/high zinc-containing amalgam and other couples(P0.05), while the currents produced by gold/low zinc-containing amalgam and titanium/high zinc-containing amalgam increased. Potential of high zinc-containing amalgam was more negative than other alloys, and it was always under anodic behavior during the experiment corrupted acceleratedly. Conclusion Dentists can′t ignore the case that the patient feels normal at the beginning of wearing different occluding metallic restorations. Either of gold/titatium, gold/high zinc-containing amalgam and low/high zinc-containing amalgam appearing in oral will do harm to the patients′ health. Neither of gold/low zinc-containing amalgam nor itanium/high zinc-containing amalgam can coexist in oral. Zinc-free or low zinc-containing amalgam should be selected instead of high zinc-containing amalgam.