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论文摘要

静磁场对牙周炎大鼠牙周膜组织中骨形成蛋白-2影响的实验研究

Effect of Static Magnetic Field on Bone Morphogenetic Protein-2 in Periodontal Membrane of Experimental Periodontitis Rat

作者:仇丽鸿,秦科,钟鸣,王兆元

Author:QIULi-hong, QINKe, ZHONGMing,WANG Zhao-yuan

收稿日期:2005-08-25          年卷(期)页码:2005,23(04):319-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:静磁场,骨形成蛋白-2,牙周炎,

Key words:static magnetic field,bone morphogenetic protein-2,periodontitis,

基金项目:辽宁省教育厅基金资助项目(20122170)

中文摘要

目的 观察静磁场对实验性牙周炎大鼠牙周膜组织中骨形成蛋白-2(BMP-2)表达的影响。方法 36只大 鼠牙周结扎、高糖喂食5周,确定形成牙周炎模型后,分为2组,每组18只。实验组在大鼠双侧颊部皮下组织区埋 入表面磁场强度为0.12 T的磁体,实验对照组埋入不充磁的磁体。2组大鼠分别于术后的第2、4、7天处死,切取牙 周炎患牙及其周围牙周组织,采用SABC免疫组化方法检测病变区牙周膜组织中BMP-2的变化。同时设正常对照 组。结果 静磁场作用后,牙周膜组织中BMP-2表达增多,第4天和第7天时与实验对照组间存在显著性差异 (P

英文摘要

Objective To evaluate the effect of static magnetic field on expression of bone morphogenetic protein-2(BMP-2) in the periodontal membrane of experimental periodontitis rat.Methods Experimental periodontitis of rat was formed by ligaturing the neck of rat teeth and feeding sugar of high concentration. The magnetwhich the intensity of magnetic field was 0·12 tesla was put intotheir cheeks. The ratswere sacrificed at 2ndday, 4thday and 7thday, respectively. Immuno-histochemical techniqueswere used to evaluate the change of BMP-2 expression.Results BMP-2 was mainly found in the plasma of fibroblast, osteoblast, ce- mentocyte and odontoblast separately. There was not clearly difference between the periodontitis group and the normal group, but BMP-2 in the experimental group treated with static magnetic field was higher than the two groups.Conclusion Static magnetic field plays an important role in repairing and remodeling of periodontitis.

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