Objective To look for the best carrier for cultivating oral tissue engineered mucosa. Methods A series of mem- brane of scaffold materials of polycleelide-co-plycoclide (PLGA)were studied on their weight and biocompatibilityafter they had been implanted subcutaneously in rabbits for 1, 2 , 3 , 4 weeks respectively. Results PLGAI，II，III degraded completely in rab- bits after 2,3,4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGAI，II，III with surrounding tissues were normal and membranes had a good biocompatibility. Conclusion The biode- grading rate of PLGA II is suitable for clinic practice. PLGA II~a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate..
