期刊导航

论文摘要

Fcγ受体IIA基因多态性与慢性牙周炎易感性的相关性研究

The Association between FcγReceptorⅡA Gene Polymorphism and Susceptibility to Chronic Periodontitis in Chinese Han Nationality

作者:唐燕,章锦才,张蕴惠,庞若愚

Author:TANG Yan1,ZHANGJin-cai2,ZHANG Wen-hui1,PANG Ruo-yu2

收稿日期:2004-04-25          年卷(期)页码:2004,22(02):158-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:Fcγ受体ⅡA,慢性牙周炎,基因多态性,

Key words:FcγreceptorⅡA,chronic periodontitis,gene polymorphism,

基金项目:国家自然科学基金资助项目(39970793)

中文摘要

目的 探讨Fcγ受体ⅡA基因多态性和慢性牙周炎的易感性相关关系。方法 采用序列特异性引物多聚酶链反应(PCR-SSP),对63例重度慢性牙周炎患者、103例轻中度慢性牙周炎患者及80名健康对照者的Fcγ受体 ⅡA基因多态性进行检测,比较各组间基因型分布及等位基因频率的差异。结果 FcγRⅡA-R/R131基因型在重度慢性牙周炎与健康对照组之间的分布差异有显著性(P0·012 5)。结论 FcγRⅡA-R/R131基因型与慢性牙周炎的严重程度相关,提示其可能与汉族人群慢性牙周炎的易感性有关。

英文摘要

Objective To investigate the association between FcγreceptorⅡAgene polymorphism and susceptibility to chron- ic periodontitis in ChineseHan nationality.Methods DNAsampleswere collectedwith buccal swabs from63 patientswith severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fcγre- ceptorⅡA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.Results It was found that the frequency of FcγRIIA-R/R131 genotype was significantly higher in patients with severe CP (19·05%) compared to that of the healthy controls (P

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