Objective Clinical data of burning mouth syndrome were investigated in detail and the relation to pain was analyzed in orderto find a clue to clinical treatment.Methods 78 patientswith burningmouth syndrome were examined carefully and 7 factors that related to the degree of pain were analyzed with multivariate stepwise regression.Results The study demon- strated that the psychological disorder, autonomic nerves system abnormity, oral dryness and high_extravasated blood level were positively related to the degree of pain.Conclusion The study suggested that psychotherapy, improvement of autonomic nerves system, treatment for oral dryness and Chinese traditional therapy of invigoration of blood circulation were of great importance in curing burning mouth syndrome.