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论文摘要

超高分子量聚DL-乳酸降解过程中的超微结构改变

Ultrastructure Characteristics of Super-high Molecular Weight Poly-DL-lactic Acid During Degradation in vitro

作者:郑谦,刘磊,魏世成,赵宗林,熊成东,罗福成

Author:Zheng Qian, Liu Lei, Wei Shicheng, et al

收稿日期:2002-08-25          年卷(期)页码:2002,20(04):286-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:超高分子量聚DL-乳酸,降解,超微结构,

Key words:poly_DL_lacticacid degradation,ultrastructure,

基金项目:

本课题为国家863计划资助项目(编号715-002-0141)

中文摘要

目的:观察超高分子量聚DL-乳酸(PDLLA)骨折内固定系统在下颌骨骨折内固定时的降解特性。方法:建立犬下颌骨骨折的实验动物模型,采用国产超高分子量PDLLA骨折内固定系统固定下颌骨骨折,通过扫描电子显微镜观察术前及术后1、3、6月可吸收接骨板在降解过程中超微结构的变化。结果:术前PDLLA材料的表面较为粗糙,但表面无明显的孔洞;术后1月,材料表面出现龟裂纹,为较浅的沟槽;术后3月,材料表面深在沟槽明显增多; 术后6月,材料表面变为完全凹凸不平的堆积物。结论:PDLLA降解时首先在表面和浅层,术后3月已逐渐深入内部,此时其力学强度也明显下降,但骨折愈合已基本完成,内固定系统开始崩解、吸收,从而避免了金属接骨板存在不利于骨折愈合的应力遮当效应。

英文摘要

Objective:The aim of this experimentwas to study the characterof degradation of super-highmolecularweight poly-DL-lactic acid (PDLLA) internal fracture-fixing system.Methods:The fracture mandible of dogswas fixed with super-high molecularweight PDLLA internal fracture-fixing system. In 1, 3, 6, 12 months afterthe operation, the materialswere taken outfrom dogs, and the palateswere observed using the scanning electron microscopy.Results:The surface of super-high molecular weight PDLLA was coarse. In 1 month after the operation, there were much chaps and grains on the surface of PDLLA. In 3 months after the opera- tion, there were much deeper grooves. In 6 months after the operation, only some scraggly accumulation was seen.Conclusion: Super-high molecularweightPDLLA can degrade on the surface in the beginning, and then the material begins to degrade deeply. The speed of degradation matches with the speed of fracture healing. Itwill help to avoid stress-protecting effect.

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