不同速率牵张山羊下颌后下齿槽血管变化与血管生成的实验研究
Changes in the Inferior Alveolar Vessels and Angiogenesis Following Mandibular Lengthening with Different Rates of Distraction
作者：唐正龙,邹淑娟,胡静,王大章,廖运茂
Author：Tang Zhenglong, Zou Shujuan, Hu Jing, et al
收稿日期：2002-06-25 年卷（期）页码：2002,20(03):203-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：牵张成骨,下齿槽血管,血管生成,
Key words：distractionosteogenesis,inferioralveolarvessel,angiogenesis,
基金项目：本课题为国家自然科学基金资助项目(编号39970797)
中文摘要
目的:研究不同速率牵张延长山羊下颌骨后下齿槽动静脉的变化和新骨组织内血管生成情况。方法:8只成年山羊随机分为3组,A组(3只)以110 mm/d牵张,B组(3只)以210 mm/d牵张,C组(2只)为对照。A、B两组均牵张延长下颌10 mm,于牵张结束固定后第2周时处死动物,取牵张区下齿槽动静脉及新骨组织行组织学和定量组织学研究,观察下齿槽血管的管壁厚度和管径大小变化,以及新骨中微血管数量变化。结果:两种速率牵张后均未见下齿槽血管壁有病理性改变,但210 mm/d组的血管管径变小,管壁变薄,与对照组相比有显著差异(P
英文摘要
Objective:The purpose of this study was to study the changes in the inferior alveolar vessels and angiogenesis following mandibular lengthening with different rates of distraction.Methods:Bilateral mandibular corticotomieswere performed in 6 goats. The mandibles in 6 goats were legnthened 10.0 mm using a custom-made distractorwith different rates of distraction (1.0 mm/d [n=3] and 2.0 mm/d [n=3]); the other2 nondistracted mandibles served as control. The goatswith distracted mandibleswere killed at2 weeks after completion of distraction. The inferior alveolar vesselswith distracted calluseswere harvested and processed for histologic and morphometric evaluation.Results:No pathological changes in the inferior alveolar vessels were found following mandibular osteodistraction. However, the number of microvessels within distraction gap in the animals distracted at a rate of 1.0 mm/day was greater than that in the goats distracted using a rate of 2.0 mm/day, and more mature newly formed bone trabeculae was observed.Conclusion:There were no significant changes in the inferior alveolar vessels aftermandibular lengthening with dis- traction osteogenesis, but rapid distraction may have adverse effects on the aniogenesis in the distraction gap.
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