Objective:The purpose of this study was to investigate the role of nuclear morphometric parameters, DNA content and Ag- NOR count in the differentiating malignant and benign ameloblastomas.Methods:Totally 17 cases of malignant ameloblastomas were examined by using HE, AgNOR and DNA stain methods. Morphometric parameters of cell nuclei, DNA content and AgNOR countwere quantitatively studied by using an image analysis system.Results:Seven parameters (area, perimeter, equal diameter, minor diameter, mean diameter, round index, axis ratio) out of ten shape factors were significantly different between malignant and benign ameloblastoma (P