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论文摘要

缺氧诱导因子-1α信号通路在髁突软骨生长和改建中的作用机制

Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth andremodeling

作者:徐高丽,吴立立,吴枝武,谷志远

Author:Xu Gaoli, Wu Lili, Wu Zhiwu, Gu Zhiyuan

收稿日期:2015-11-21          年卷(期)页码:2016,34(6):639-639-642

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:缺氧诱导因子-1α,髁突软骨,低氧,静压力,

Key words:hypoxia-inducible factor-1α,condylar cartilage,hypoxic,static pressure,

基金项目:国家自然科学基金(81170979);浙江省医药卫生科技计划项目(2015KYB146)

中文摘要

髁突软骨在正常机体内处于一个低氧环境中,软骨细胞却对此表现出较好地适应能力,然而在体外细胞的研究中发现,髁突软骨细胞在传代培养中很难保持稳定性,这为髁突软骨的研究带来了较大困难。同时也考虑培养髁突软骨细胞时是否应尽可能模拟体内低氧环境。缺氧诱导因子-1α(HIF-1α)是细胞对低氧环境适应性反应的重要转录因子,对维持软骨细胞的稳态和功能具有重要意义。本文就HIF-1α的生物活性结构、相关信号通路及在髁突软骨修复中的作用作一综述。

英文摘要

The condylar cartilage was adapted to hypoxic conditionsin vivo. However, condylar cartilage cells exposedin normoxiain vitroaffect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in greatdifficulty in chondrocyte research. Culturing chondrocyte should be simulated inin vivohypoxia environment as much aspossible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response tohypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This reviewsummarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilagerepair.

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