ObjectiveThis study aimed to explore the impacts of periodontitis on the visceral weight and weight percen-tage of obese animal models.MethodsA total of 64 C57BL/6J mice were divided into the following diet groups: high-fat diet (HFD) group (n=36), which was fed with high-fat diet to induce obesity, and low-fat diet (LFD) group (n=28), which was fed with low-fat diet as the control. After 16 weeks on diet, each diet group was divided into periodontitis (P) and control (C) groups. The P groups were induced for periodontitis by ligation withPorphyromonas gingivalis-adhered silk for 5 or 10 days, and the C groups were sham-ligated as the control. Visceral organs were resected and weighed. The organ weight percentage was calculated.ResultsCompared with the LFD group, the HFD group significantly upregulated the weight and weight percentage of visceral adipose tissue and spleen (PPPPPConclusionPeriodontitis can affect the general morphology of the viscera (especially spleen) in obese animal models. Pathological indications in terms of immunometabo-lism might be present in the correlation between obesity and periodontitis.
