人体微生物组在辅助2型糖尿病诊疗中的潜在应用
Potential application of human microbiomes in the diagnosis and treatment of type 2 diabetes mellitus
作者：刘云坤,徐欣,周学东
Author：Liu Yunkun,Xu Xin,Zhou Xuedong
收稿日期：2019-04-15 年卷（期）页码：2019,37(5):556-556-562
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：2型糖尿病,口腔微生物组,肠道微生物组,精准医疗,
Key words：type 2 diabetes mellitus,oral microbiome,gut microbiome,precision medicine,
基金项目：国家自然科学基金(81430011);国家自然科学基金(81670978);四川省科技厅重大前沿项目(2016JY0006)
中文摘要
人体微生物组是指人体体表及内部的微生物的遗传信息总和,与人类健康与疾病状态存在密切关系。口腔和肠道微生物是最具多样化的微生物群落,两者可以交互影响,在疾病发生发展过程中共同发挥作用,并可以实时反映机体的健康与疾病状态。2型糖尿病是由遗传和环境因素引起的代谢紊乱,最近的研究指出微生物与糖尿病存在关联。本文结合近期的研究进展,就2型糖尿病患者口腔微生物和肠道微生物的特征进行综述,有望为探索基于微生物组特征的2型糖尿病风险预测、诊断和预后预测的疾病模型的建立提供参考依据。
英文摘要
Human microbiome refers to the total microorganism genetic information of human body surface and internal, which is closely related to human health and disease. Oral and gut microbiomes are the most diverse microbial communities, which can interact and play a role in the development of the disease, and can reflect the health and disease state in real time. Type 2 diabetes mellitus is a metabolic disorder caused by both genetic and environmental factors. Recent research has shown a link between microbes and diabetes. This article reviewed the latest research on the changes of oral and gut microbiomes in type 2 diabetes mellitus patients, which expects to provide a reference for exploring the development of the disease model for prediction, diagnosis and prognosis of type 2 diabetes mellitus based on human microbiome characteristics.
【关闭】
