ObjectiveThis work aimed to evaluate the effect of different surface treatments on the shear bond strength of resin nano ceramic to resin cement, thereby providing a theoretical basis for the improvement of clinical application.MethodsA total of 150 specimens (10 mm×10 mm×3 mm) were milled from resin nano ceramic blocks (Lava Ultimate) using computer-aided design/computer aided manufacturing(CAD/CAM) technology. The specimens were randomly divided into five groups according to the surface treatment performed, as follows: control, sandblasted, sandblasted+silane, hydrofluoric acid, and hydrofluoric acid+silane groups. After the corresponding surface treatment, the specimens were cemented using Single Bond Universal Adhesive and RelyXTMUltimate ClickerTMadhesive resin cement. All cemented specimens were placed in distilled water for 24 h and 30 days and subjected to a shear bond strength test in a universal testing machine.ResultsThe surface treatment and water storage periods showed significant effects on bond strength. Surface treatment with sandblasted+silane showed the highest shear strength values among all tested groups, and the difference was statistically significant (P<0 .05). a difference was observed between the control and hydrofluoric acid groups, and both had significantly difference compared with other groups (P<0 .05). sandblasted and hydrofluoric acid+silane groups were not statistically different, and both had significantly difference compared with other groups (P<0 .05).ConclusionThe surface of resin nanoceramic treated by sandblasted, sandblasted+silane, and hydrofluoric acid+silane can improve the bond strength. The sandblasted+silane group had the best the shear bond strength among the groups.