ObjectiveTo study the changes of tear film after short-term overnight orthokeratology wearing in adult myope.MethodsFifty adult myope aged 18 to 38 years old were enrolled in this study. The patients wore orthokeratology 6-10 h every night during this study. Data such as non-invasive tear break-up time (NITBUT), fluorescent tear break-up time (FTBUT), lower tear meniscus height (LTMH), corneal fluorescent staining as well as ocular surface disease index (OSDI) questionnaire score were measured at baseline, 1 d, 7 d, 14 d, 30 d and 90 d.ResultsForty-four subjects completed the follow-up study. Tear break-up time (TBUT) decreased and became stable at 14 d after overnight orthokeratology wearing. LTMH sustained decreased and there was a difference after 90 d overnight wearing （P<0 .05）. compared with baseline, the grade of corneal staining increased at all time points （P<0 .05）. as for the osdi score, there was no difference at all time points.ConclusionAfter overnight orthokeratology wearing, tear film stability and tear secretion decreased. Adult myope seems easily to suffer corneal injury after overnight orthokeratology wearing.
