ObjectiveTo study the expression of ubiquitin C-terminal hydrolase-L3 (UCH-L3) in epithelial ovarian cancer (EOC) tissues, and to analyze the relationship between UCH-L3 expression and the clinic pathological characteristics and prognosis of EOC patients.MethodsImmunohistochemical analysis was performed to evaluate UCH-L3 expression in different ovarian epithelial tissue specimens. The correlation between UCH-L3 expression and clinical pathologic parameters, prognosis and of EOC was statistically analyzed.ResultsThe expression level of UCH-L3 in EOC was higher than that in benign ovarian tumor and normal ovary (P< 0.05). the positive expression level of uch-l3 in late figo group, high-level group, group with intraperitoneal metastasis were significantly higher than that in early figo group (P=0.006), low-level group (P=0.001), group without intraperitoneal metastasis (P=0.032). There was no significant difference in survival time between the high and low expression groups of UCH-L3.ConclusionUCH-L3 may play a role in EOC pathogenesis and progression.
