期刊导航

论文摘要

c-myb、Bax蛋白在子宫内膜癌中的表达及意义

Expression and Clinical Significances of c-myb and Bax Proteins in Endometrial Carcinoma

作者:冯余宽, 吕琳, 张雅晴等

Author:FENG Yu-kuan, LÜ Lin, ZHANG Ya-qing. et al

收稿日期:          年卷(期)页码:2014,45(5):797-800

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:c-myb Bax 子宫内膜癌

Key words:c-myb Bax Endometrial carcinoma

基金项目:

中文摘要

目的 探讨c-myb、Bax蛋白在子宫内膜癌中的表达和意义。方法 应用免疫组化SP法和TUNEL技术对68例子宫内膜样腺癌组织和42例正常子宫内膜组织中c-myb、Bax蛋白表达和细胞凋亡指数进行检测,结合临床病理指标进行分析。结果 c-myb、Bax在子宫内膜癌组织中的阳性表达率高于正常子宫内膜组织(PPr=0.529, PP>0.05)。结论 子宫内膜癌中存在c-myb、Bax蛋白的高表达,c-myb参与肿瘤细胞的增殖分化调节,Bax调节肿瘤细胞凋亡,两者可作为判断子宫内膜癌恶性行为和预后的指标。

英文摘要

Objective To study the expressions of c-myb and Bax proteins and their relationships with clinic-pathological characteristics in endometrial carcinoma. Methods The expressions of c-myb and Bax protein were detected by immunohistochemistry in 42 normal endometrial tissues and 68 endometrial carcinoma tissues. Apoptosis index was detected by TUNEL technique. Results The positive expression rates of c-myb and Bax in endometrial carcinoma were significantly higher than those in normal endometrial tissues (PPPPP>0.05). Conclusion Endometrial carcinoma has high expression of c-myb and Bax, and the expression status of both c-myb and Bax may be related to the malignant degree and prognosis of endometrial carcinoma.

关闭

Copyright © 2020四川大学期刊社 版权所有.

地址:成都市一环路南一段24号

邮编:610065