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论文摘要

血浆IL-6、CRP和TNF-α水平在主动脉夹层患者病程中的变化及意义

Clinical Significances of Plasma Interleukin-6,C-reaction Protein and Tumor Necrosis Factor-α in Patients with Aortic Dissection

作者:钟明华, 古君, 张尔永

Author:ZHONG Ming-hua, GU Jun, ZHANG Er-yong

收稿日期:          年卷(期)页码:2015,46(2):234-237

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:主动脉夹层炎症因子全身炎症反应变化趋势

Key words:Aortic dissectionInflammatory factorSystemic inflammatory responseTrends

基金项目:

中文摘要

目的 通过检测主动脉夹层患者血浆中白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)和C-反应蛋白(CRP)3种炎症介质的浓度,探讨其在病程中的变化及临床意义。 方法 分别使用ELISA法检测68例主动脉夹层患者、50例单纯原发性高血压患者及50例健康成人血浆中的IL-6、CRP、TNF-α浓度,将主动脉夹层组按照病程不同分为包含急性期到慢性期的9个时间段组别进行统计,分析夹层组炎症介质与另两组的差异及其随时间的变化趋势。 结果 主动脉夹层患者血浆中IL-6、CRP、TNF-α浓度均比正常人组、单纯原发性高血压组高(\P

英文摘要

Objective To investigate the clinical significances of plasma IL-6, CRP and TNF-α concentration changes in aortic dissection. Methods Plasma concentrations of IL-6, TNF-α and CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers.The changes of plasma IL-6, CRP and TNF-α concentration were analyzed in aortic group along with the progression of the disease which was divided into 9 different time courses. Results Compared with essential hypertension and healthy control group,significantly elevated CRP,IL-6 and TNF-α concentrations were detected in aortic dissection patients (\P

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