期刊导航

论文摘要

免疫固定电泳和血轻链比值诊断以肾脏损伤为首发症状的多发性骨髓瘤的价值

Diagnostic Value of Cystain C in Contrast Associated Acute Kidney Injury after Transcatheter Closure forChildren with Congenital Heart Disease

作者:唐江涛, 李立新, 冯伟华等

Author:TANG Jiang-tao, LI Li-xin, FENG Wei-hua. et al

收稿日期:          年卷(期)页码:2016,47(4):551-555

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:多发性骨髓瘤 肾脏损伤 免疫固定电泳 血轻链

Key words:Multiple myeloma Renal injury Immunofixation electrophoresis Light chain

基金项目:

中文摘要

目的 探讨血清免疫固定电泳和血清轻链比值测定在以肾脏损伤为首发症状的多发性骨髓瘤(MM)患者中用于实验室诊断与鉴别诊断的价值。 方法 肾脏疾病患者共822例进行血清免疫固定电泳、血清轻链测定及免疫球蛋白定量,同时检测患者肾脏功能,包括尿素(BUN)、肌酐(Crea)、胱抑素C(Cys-C)以及估算肾小球滤过率(eGFR)。分析血清免疫固定电泳和血清轻链比值测定在诊断和鉴别诊断原发性肾脏损伤疾病以及MM继发肾脏损伤疾病中的临床应用价值。 结果 822例患者中9.1%(75/822)患者出现M蛋白。其中IgG型49.3%(37/75),IgA型34.7%(26/75),IgM型5.3%(4/75),单纯轻链Lambda(LAM)10.7%(8/75)。Kappa(KAP)/LAM比值在M蛋白组和非M蛋白组间比较差异有统计学意义,以KAP型轻链表达为主的M蛋白组高于非M蛋白组、以LAM型轻链表达为主的M蛋白组低于非M蛋白组( P均 P均

英文摘要

Objective To explore the diagnostic value of immunofixation electrophoresis and Kappa/Lambda (KAP/LAM) ratio in multiple myeloma patients with renal injury. Methods The serum of 822 patients of renal disease were collected for the examnation of immunofixation electrophoresis, KAP/LAM ratio, serum immunoglobulin levels and renal function,including serum urea nitrogen (BUN), serum creatinine (Crea), cystatin C (Cys-C) and estimated glomerular filtration rate (eGFR). To analyze the diagnostic value of immunofixation and KAP/LAM ratio in the differentiation of renal injury of multiple myeloma from primary renal injury diseases. Results M protein was observed in 75 patients (9.1%). The ratio of each type was IgG 49.3%(37/75), IgA 34.7%(26/75),IgM 5.3%(4/75) and LAM 10.7%(8/75). There was significant difference of KAP/LAM ratio between M protein group and non-M protein group. The KAP/LAM ratio was significant higher in KAP group, compared to non-M protein group. Reverse result was obtained in LAM group. There were higher Crea level and lower eGFR value in pure LAM light chain group, compared with IgG, IgA and IgM groups. Conclusion Immunofixation electrophoresis and KAP/LAM ratio may play an important role in the diagnosis of multiple myeloma patients with renal injury, so could be early screening markers.

关闭

Copyright © 2020四川大学期刊社 版权所有.

地址:成都市一环路南一段24号

邮编:610065