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论文摘要

Livin和PTEN在卵巢子宫内膜异位症癌变组织中的表达和相关性研究

Expressions of Livin and PTEN in Cancerous Tissues of Ovary Endometriosis

作者:刘星娅, 王红静, 徐盼等

Author:LIU Xing-ya, WANG Hong-jing, XU Pan. et al

收稿日期:          年卷(期)页码:2016,47(4):512-515

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:卵巢子宫内膜内异症癌变 凋亡抑制基因 Livin PTEN 相关性 免疫组织化学

Key words:Ovary endometriosis cancerization Apoptosis inhibitor gene Livin PTEN Correlation Immunohistochemistry

基金项目:

中文摘要

目的 探讨Livin、PTEN蛋白在卵巢子宫内膜异位症癌变组织中的表达及其相关性。方法 采用免疫组织化学EliVision法检测19例卵巢子宫内膜异位症癌变组织、30例卵巢子宫内膜异位症组织和30例卵巢良性肿瘤组织中Livin 及PTEN蛋白的表达。结果 Livin在卵巢子宫内膜异位症癌变组织中的阳性表达率(68%)高于卵巢子宫内膜异位症(36%)和卵巢良性肿瘤(13%)( P P>0.05);PTEN在卵巢子宫内膜异位症癌变组织中的阳性表达率(16%)低于卵巢子宫内膜异位症(65%)和卵巢良性肿瘤(80%)( P P>0.05);卵巢子宫内膜异位症癌变组织中Livin与PTEN表达呈负相关( r=-0.559, P=0.001)。结论 Livin表达上调和PTEN表达缺失与卵巢子宫内膜异位症癌变的发生、发展有关。

英文摘要

Objective To investigate the expressions of Livin and phosphate and tension homology deleted on chromsome ten (PTEN) protein in the cancerous tissues of ovary endometriosis. Methods Immunohistochemistry EliVision was used to examine the expressions of Livin and PETN protein in 19 samples of ovary endometriosis cancerous tissues, 30 samples of ovary endometriosis tissues and 30 samples of ovarian benign tumor tissues. Results The positive expression rate of Livin in ovary endometriosis cancerous tissues (68%) was obviously higher than that in ovary endometriosis tissues (36%) and benign tumor tissues (13%)( P P P>0.05), the same result was also found for PTEN. Livin and PTEN expression presented an obviously negative correlation in ovary endometriosis cancer ( r=-0.559, P=0.001). Conclusion Up-regulation of Livin expression and down-regulation of PTEN may be involved in the occurrence and development of ovary endometriosis cancerization.

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