Objective To evaluate the clinical effectiveness and safety of autologous platelet-rich gel ( APG) in the treatment of chronic skin ulcer with tophus．Methods Four patients of chronic skin ulcer with tophus received routine debridement to remove necrotic tissue and erasion tophus as far as possible，and then received the treatment of APG．Results All of the patients had their wounds healed after the treatment of APG （one wound was treated twice）． The wounds were healed between 8 to 22 d, average (13.7±6.8) d, while there were no adverse effects observed．Conclusion Topical therapy with APG may be considered as an effective and safe adjuvant method for the treamtment of chronic skin ulcer with tophus．
