Objective To determine the effects of Huoxue Dingxuan Capsule on vertebral artery blood flow, plasma plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in rats with cervical spondylosis of vertebral artery type (CSA). Methods Ninety healthy male Wistar rats were equally and randomly divided into control, model and treatment groups. The rats in the model and treatment groups were subject to composite modeling manufacturing CSA. The treatment group was given six-week interventions with Huoxue Dingxuan capsule 4 weeks after the modeling. Vertebral artery blood flow, plasma PAI, and t-PA contents were detected before modeling, prior to the interventions, and post interventions. Results Before the interventions, the rats in the model and treatment groups had significantly lower blood flow of vertebral artery than the controls (PPPPPP
