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论文摘要

胃间质瘤组织FAP的表达及其与预后的相关性分析

FAP Expression and Its Association with the Prognosis of Gastric Stromal Tumors

作者:汤苏敏, 沈朝勇, 尹源等

Author:TANG Su-min, SHEN Chao-yong, YIN Yuan. et al

收稿日期:          年卷(期)页码:2017,48(2):234-238

期刊名称:四川大学学报(医学版)

Journal Name:JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION)

关键字:胃间质瘤 FAP 预后

Key words:Gastric stromal tumors FAP Prognosis

基金项目:

中文摘要

【摘要】 目的 探讨胃间质瘤(GSTs)组织中成纤维细胞活化蛋白(FAP)的表达情况及其与预后的相关性。方法 收集2010年1月至2013年12月间我院病理科保存的GSTs石蜡标本,通过免疫组化染色检测FAP表达;另取GSTs高、低恶性度患者新鲜肿瘤组织,进行FAP蛋白芯片分析,分析FAP与肿瘤临床病理特点及患者预后间的关系。结果 本研究共纳入98例符合标准的病例,通过免疫组化染色显示FAP表达于GSTs细胞的胞浆,阳性表达率为42.9%,在正常胃组织中不表达。在不同性别、年龄及核分裂象数的患者中,FAP表达差异无统计学意义(P 均>0.05);而在不同肿瘤长径和危险度分级患者中,FAP表达差异有统计学意义(P 均P 均P 均

英文摘要

【Abstract】 Objective To determine the association of FAP expression with the prognosis of gastric stromal tumors (GSTs). Methods Paraffin-embedded GSTs samples were collected from January 2010 to December 2013 in the department of pathology of our hospital. FAP expression was examined by immunohistochemistry staining. Its correlations with clinical pathological characteristics and prognosis of GSTs were analyzed. Results A total of 98 cases were included in this study. FAP was expressed in the cytoplasm of GSTs cells, with a positive rate of 42.9%. No FAP expression was found in normal gastric tissues. No differences of FAP expression were found in patients with different gender, age and tumor mitotic counts (P >0.05). Tumor diameter and risk classification were associated with FAP expression (P P P

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