【Abstract】 Objective To determine the underlying mechanism of Gubentongluo Formula in the treatment of IgA nephropathy (IgAN). Methods C57BL/6 mice were randomly divided into four groups: normal group （n =10）, IgAN group （n =10）, control group （n =10） and treatment group （n =10）. Mice in the normal and IgAN groups were intragastricly administered with normal saline for 12 weeks; while those in the control and treatment groups were given fenofibrate 〔30 mg/(kg·d) and Gubentongluo Formula 〔1.67 mL/(g·d)〕, respectively. Urinary albumin was detected at week 0 and 12. At week 12, protein expressions of peroxisome proliferstor activated receptor α (PPARα), liver fatty acid-binding proteins (L-FABP), 4-hydroxy-2-nonenal (4-HNE), and hemeoxygenase-1(HO-1) in renal tissues were determined by Western blot; mRNA expressions of PPARα and L-FABP in renal tissues were determined by florescent quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results At week 12, higher levels of urinary albumin, pathological injuries in glomerular mesangial area, and lower expressions of protein and mRNA of PPARα and L-FABP were found in mice in the IgAN group compared with those in the normal group (P P P
