Objective To investigate the effect of He-Ne laser therapy on wound healing after nail surgery. Methods Patients who needed nail surgery were divided into treatment group (n=20) and control group (n=20) randomly.The He-Ne laser was applied to the wound after nail surgery in treatment group. The wound healing time, the inflammation duration, the pain rating, and the nail plate full-grown time were compared with control group. Results No significant differences in baseline of two groups were observed. The wound healing time was (16.00±2.51) d in control group and (11.35±1.73 ) d in treatment group,the inflammation duration was (9.10±2.10) d in control group and (7.20±1.44) d in treatment group (PPP>0.05).The pain rating of the 2 groups was different from 25 h (after 3 times treatment)(P