期刊导航

论文摘要

掺锶聚磷酸钙的微观结构、体外降解性能和血管内皮细胞相容性研究

Study on the Microstructure, Degradation in vitro and the Cytocomptibility to Vascular Endothelial Cells of Strontium doped Calcium Polyphosphate

作者:陈元维(四川大学 高分子科学与工程学院,四川 成都 610065);史国齐(四川大学 高分子科学与工程学院,四川 成都 610065);秦滢杰(四川大学 高分子科学与工程学院,四川 成都 610065)

Author:(School of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China);(School of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China);(School of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China)

收稿日期:2006-02-20          年卷(期)页码:2006,38(6):98-103

期刊名称:工程科学与技术

Journal Name:Advanced Engineering Sciences

关键字:掺锶聚磷酸钙;血管内皮细胞;细胞相容性

Key words:strontium-doped calcium polyphosphate; vascular endothelial cells; cytocompatibility

基金项目:国家自然科学基金资助项目( 30370411;50472091 )

中文摘要

以聚磷酸钙(CPP)为对照,研究掺锶聚磷酸钙(SCPP)微观结构、体外降解产物和速率以及血管内皮细胞相容性,探讨了掺锶对CPP结构性能的影响。结果表明,掺锶改变材料的微观结构与降解性能。与CPP相比,SCPP材料晶粒变大,晶粒间连接更紧密形成平整表面;14 d SCPP降解释放的Ca2+和Pi浓度显著下降,即降解速率变慢,降解产物中出现Sr2+,且浓度随时间增加。体外细胞培养结果显示,掺锶能提高材料与血管内皮细胞的相容性。SCPP表面内皮细胞更易粘附、铺展,融合生长形成单层内皮覆盖材料表面。SCPP降解液能显著促进内皮细胞的增殖(p

英文摘要

With the calcium polyphosphate(CPP) as a control, the microstructure, degradation in vitro and the cytocomptibility to vascular endothelial cells(VECs) of strontium-doped calcium polyphosphate(SCPP) were investigated, and the effects of strontium on the structure and properties of CPP scaffold were discussed. The crystalline grain of SCPP were enlarged, which linked together more tightly and developed a smoother surface. Moreover, the degradation rate of SCPP was slower. In the degradation fluid of SCPP, strontium was detected, the concentration of which increased with time. The cytocompatibility of SCPP was promoted apparently. The VECs on the SCPP scaffold attached more quickly and fully spreaded, developing a monolayer endothelium and wrapping the surface of scaffold. After cultured with the degradation fluid of SCPP, cell proliferation ability was up-regulated significantly(p

关闭

Copyright © 2020四川大学期刊社 版权所有.

地址:成都市一环路南一段24号

邮编:610065