With the calcium polyphosphate(CPP) as a control, the microstructure, degradation in vitro and the cytocomptibility to vascular endothelial cells(VECs) of strontium-doped calcium polyphosphate(SCPP) were investigated, and the effects of strontium on the structure and properties of CPP scaffold were discussed. The crystalline grain of SCPP were enlarged, which linked together more tightly and developed a smoother surface. Moreover, the degradation rate of SCPP was slower. In the degradation fluid of SCPP, strontium was detected, the concentration of which increased with time. The cytocompatibility of SCPP was promoted apparently. The VECs on the SCPP scaffold attached more quickly and fully spreaded, developing a monolayer endothelium and wrapping the surface of scaffold. After cultured with the degradation fluid of SCPP, cell proliferation ability was up-regulated significantly(p