The comprehensive study on apple juice fermentation by means of a novel PDMS membrane bioreactor was conducted, with a scale up membrane module. The bioreactor system worked stably and the separation performance of the composite PDMS membrane was good. By two-stage condensation, an apple brandy with suitable ethanol concentration was obtained, which has strong apple aroma and alcohol flavor. The retentate after pervaporation, which has rich nutrition and plenty of organic acids, can be made into acidic beverage.