The numerical simulations for the benchmark test of a 12-story reinforced concrete frame model carried out in Tongji University in 2003 were conducted in consideration of cumulative effect caused by series of earthquake events in platform of OpenSees. Meanwhile the damage status of the model was evaluated by using the System Identification toolbox of OpenSees formed by the principle of the improved direct stiffness method. Through comparison with the damaging description in several cases during the test, it is demonstrated that the preliminary assessment by using the System Identification Toolbox to conduct damage detection of 3-D frame structures in different direction are feasible and effective.