Restricted by terrain, a large number of roads and railways often appear along the reservoir line and along the river line, and water level changes are an important factor causing landslides on the banks. At present, most of the researches on slope seepage focus on the unsaturated uniform flow, and the study on the non-equilibrium flow of macropore slope is still lagging behind. In this study, the stability factor of unsaturated seepage flow and unsaturated macropore flow slope was analyzed, and the influence law of the factors including water level rise rate (v), hydraulic conductivity in macropores (Ksf), hydraulic conductivity of the matrix-fracture interface (Ksa), the equivalent diffusion distance between two domains (a), and the volumetric fraction of macropore domain (wf) on the stabilization of slope were analyzed by macropore flow model. The results showed that the water content in the matrix area of the slope was close to saturation in the unsaturated macropore flow, and the water content in the matrix domain was obviously less than that in the matrix domain of the slope under unsaturated macroporous seepage with rise of the water level. The hydraulic gradient of the shallow inward slope was obviously larger than that of the unsaturated large pore flow slope under unsaturated seepage. The moisture content in the matrix domain was much larger than that in the macropore domain (up to 18.9 times) at the same location because the permeability coefficient of matrix domain is much smaller than that of macroporous domain. The stability factor of reservoir bank slope decreased first and then increased with the increase of reservoir water level, and it reached the minimum at the same water level (close to the height of the highest storage level ) at the same time. Under the same seepage conditions, the stability of unsaturated macropore flow was weaker than that of unsaturated seepage. ReducingKsf,a,wfor increasingKsamade the water exchange between the two regions become slow. As the moisture rapidly migrates to the depth of the slope, it caused the groundwater level to rise and the maximal decrease of slope stability was 17.7%. The influence ofv,Ksfandwfslope stability was relatively large and equivalent, whileKsaandawere relatively small and they were about half of the former.