Abstract: In order to solve the mutual interference problem in heterogeneous networks, coordinated multi-point (CoMP) transmission technology was proposed to interference elimination for heterogeneous networks. When the end users configure multiple antennas, the coordinated transmission delay and channel quantization errors were considered jointly how to affect the interference elimination. By mathematical theory, the system throughput loss caused by the negative factors was analyzed, and the theoretical throughput loss upper bound was obtained. The simulation results showed that the throughput loss can be decrease by CoMP technology, which was meaningful for the actual system.