To establish a new design method of anchorage cable that is more dependable or reliable than the commonly used uniform design method and the integral principle based non uniform design method, the theoretical P-S relationship of anchorage cable, which is accordant with some P-S curves gained from on site pullout test, was deduced and investigated, basing on load transfer principle and constitutive model of interface between mortar and surrounding rock or soil. An on site pullout test based design method, as a dynamic feedback design method, was proposed. The design parameters in this method, such as contact rigidity and elastic shear displacement of interface between mortar and surrounding rock or soil, were calculated from P-S curve obtained from on-site pullout test that can synthetically embody complex engineering conditions, and quantitative design permitting plastic yielding of interface is viable. To demonstrate the realization approach of the new design method, a calculation example was given. The result showed that the new design method is more sound or rational than the conservative and traditional uniform design method,although its practical application in engineering may need further tests in the future.