The optimum range of parameters of lead rubber bearing (LRB) for large scale base-isolated tank on different sites is a crucial problem in the research of isolated tank. The Bouc-Wen model was adopted to simulate the non-linear hysteretic characteristics of force-displacement relationship for LRB.The nonlinear equations of motion of isolated tank was solved by the Newmark’s step-by-step method and Runge-kutta method. The seismic response of the large scale based-isolated storage tank with LRB was investigated And the influence of LRB parameters on the response of large scale base-isolated tank on different sites was analyzed. The result indicated that the isolation frequency is the primary parameter that affects the seismic response of the isolated tank. The optimal ranges of isolation frequency of large scale base-isolated tank for site I, site II, site III , and site IV are 0.5~5 rad/s, 2~5 rad/s, 2~5 rad/s and 1.5~3 rad/s respectively. The influence of the yield strength on the seismic response of tank depends on the site type and isolation frequency. There are optimum yield strength that make the base shear attain the minimum value on site II and site III. Further, the optimum yield strength increases as the isolation frequency increases.