Near infrared spectroscopy (NIR) technology with chemometric techniques was applied to fast analyze various parameters in the process of Simvastatin tablets producing.The four parameters including water content,compression force,tablet hardness and Simvastatin content were monitored by NIR quantitative analysis model,which used partial least squares (PLS) method.The correlation coefficient (R),root mean square error of calibration (RMSEC),root mean square error of prediction (RMSEP) and root mean square error of cross-validation (RMSECV) were used to assess the predictive ability and robustness of the different PLS models.The results showed that this method was validated for monitoring the four parameters in Simvastatin tablets production.
