In cold regions of west China,freeze-thaw environment is one of the main factors for leading to the damage of concrete.The freeze-thaw cycling experiment was conducted on concrete under water-saturated conditions,the uniaxial compression experiments were carried out on different freeze-thaw cycles,and the mechanical properties of concrete specimen was systematically analyzed from the perspective of damage and energy dissipation.After freeze-thaw test,the meso-structures of the concrete specimens were preliminary researched by CT meso-test method. Then the failure forms of the specimens under water-saturated and the changes of the mass, the complete stress-strain curves,uniaxial compressive strengths,energy dissipation and the variation characteristics of meso-structures of the concrete specimens after different freeze-thaw cycles were obtained.The main physic-mechanical properties and fracture law of concrete weres explained under freeze-thaw environment. The results can provide the theory basis for major engineering freeze-thaw catastrophe prediction and prevention research in the cold region.