By establishing the real-time dynamic mapping relationship between the set of the actual construction state and the set of the emulation mode of the three dimensional and full scale numerical model, with numerical simulation technology as the main means, and combining with parallel computing method, the function of coupling real-time simulation of structure safety and schedule during the full process of construction was realized. The bad geological conditions were mapped to the numerical model, then according to the real-time simulation results, the prediction and evaluation of the structure safety with bad geological conditions were made, treatment measures were put forward if the safety of construction state does not meet requirements, and the treatment effect was predicted by real-time numerical simulation. The determined treatment measures were converted to construction parameters to feedback to construction schedule control system, and the influence on the construction schedule caused by treatment measures was evaluated simultaneously. Finally, based on a mixed programming technology with Python and VB.net, a large-scale underground cavern group construction structure safety and schedule coupling real-time simulation system was developed. The system realized the field office integration of underground cavern group construction safety and schedule control, which provides great technical support to safety and schedule control of underground cavern group construction.