The uncertainty of parameters in temperature control per-simulation is inevitable and affects the accuracy of calculation results and reasonable temperature control scheme. In order to solve this problem, a method of interval analysis was introduced for interval distribution characteristics and the lack of statistical data for these uncertain factors, and corresponding interval finite element equation was derived as well. Based on perturbation theory and interval principle of monotony and studies of relationship between various uncertain parameters and concrete temperature field results, a method for “the most narrow” solution of whole interval equation was proposed. The iterative calculation method of concrete structure’s pipes cooling temperature field with uncertain cooling scheme was proposed. Interval finite element simulation program was developed with Fortran, one site non-adiabatic temperature rise experiment was simulated with this program, and its effectiveness and accuracy were verified by the measured data.