An anisotropic left ventricular (LV) model was composed by non-linear finite element method to relate regional ischemic effect of the LV to the global cardiovascular system. Several parameters from LV model were used to drive the circulatory model updating the LV model at each time step. A compound three-dimensional LV model was built to mimic regional myocardial ischemic pathological with myocardial fiber structure built in the element of the LV model. A ventricular wall tissue fiber structure was innovatively applied in the cardiovascular system model. It provided a unique platform for medicine predictions. The validity of the model system was given by the good agreement with statistical data.
